TABLE 1.
84 membrane-associated E3 ligases.
| Uniprot ID | Name | Subcellular location | Type | Transmembrane regions |
|---|---|---|---|---|
| Q9NZS9 | BFAR | ERM | RING | 4 |
| Q9UKV5 | AMFR | ERM | RING | 7 |
| Q5T197 | DCST1 | PM | RING | 6 |
| Q9Y4D8 | HECTD4 | Membrane | HECTc | 1 |
| Q96J02 | ITCH | PM, cytoplasm, nucleus, EM | HECTc | NA |
| Q8TDB6 | DTX3L | Cytoplasm, nucleus, EM, LM | RING | NA |
| A6NNE9 | MARCHF11 | VM | RING | 2 |
| Q86UD3 | MARCHF3 | VM, EM | RING | 2 |
| Q9P2E8 | MARCHF4 | GAM | RING | 2 |
| Q9NX47 | MARCHF5 | MM, ERM | RING | 4 |
| Q8TCQ1 | MARCHF1 | GAM, LM, VM, EM, PM | RING | 2 |
| Q86YJ5 | MARCHF9 | GAM, LM | RING | 2 |
| Q9P0N8 | MARCHF2 | ERM, LM, EM | RING | 2 |
| Q5T0T0 | MARCHF8 | VM, LM, EM | RING | 2 |
| Q86YT6 | MIB1 | Cytoplasm, SK, CK, PM | RING | NA |
| Q7L5Y9 | MAEA | Cytoplasm, nucleus, PM, SK | RING | NA |
| O60337 | MARCHF6 | ERM | RING | 14 |
| Q00987 | MDM2 | Cytoplasm, nucleus | RING | NA |
| Q969V5 | MUL1 | MM | RING | 2 |
| Q8WY64 | MYLIP | Cytoplasm, PM | RING | NA |
| P46934 | NEDD4 | Cytoplasm, PM | HECTc | NA |
| O76050 | NEURL1 | Cytoplasm, PM | RING | NA |
| Q6ZNB6 | NFXL1 | Membrane | RING | 1 |
| O60683 | PEX10 | Peroxisome membrane | RING | NA |
| O00623 | PEX12 | Peroxisome membrane | RING | 2 |
| O43164 | PJA2 | Cytoplasm, PM, ERM, GAM | RING | NA |
| Q8WZ73 | RFFL | EM | RING | NA |
| O00237 | RNF103 | ERM | RING | 4 |
| Q9H920 | RNF121 | Membrane | RING | 6 |
| O60260 | PRKN | Cytoplasm, nucleus, ERM, MM, PM | RING | NA |
| Q9H9V4 | RNF122 | GAM, ERM | RING | 1 |
| Q9ULX5 | RNF112 | Cytoplasm, nucleus, VM, PM | RING | 2 |
| Q96EQ8 | RNF125 | GAM | RING | NA |
| P29590 | PML | Cytoplasm, nucleus, ERM | RING | NA |
| Q8WVZ7 | RNF133 | ERM | RING | 1 |
| Q8WU17 | RNF139 | ERM | RING | 12 |
| Q86XS8 | RNF130 | Membrane, cytoplasm | RING | 1 |
| P50876 | RNF144A | PM, VM | RING | 1 |
| Q7Z419 | RNF144B | MM, cytoplasm | RING | 1 |
| Q8WVD5 | RNF141 | Membrane | RING | NA |
| Q8N8N0 | RNF152 | LM | RING | 1 |
| Q8TEB7 | RNF128 | M, cytoplasm, SK, perinuclear region | RING | 1 |
| Q9H6Y7 | RNF167 | M | RING | 1 |
| Q8NC42 | RNF149 | Membrane | RING | 1 |
| Q96MT1 | RNF145 | ERM | RING | 14 |
| Q8N7C7 | RNF148 | Membrane | RING | 1 |
| Q9ULK6 | RNF150 | Membrane | RING | 1 |
| Q96K19 | RNF170 | ERM | RING | 3 |
| Q8N4F7 | RNF175 | Membrane | RING | 5 |
| Q96D59 | RNF183 | ERM, GAM, LM | RING | 1 |
| Q9NXI6 | RNF186 | ERM | RING | 2 |
| Q8N6D2 | RNF182 | Membrane, cytoplasm | RING | 2 |
| Q9Y6U7 | RNF215 | Membrane | RING | 2 |
| Q9NV58 | RNF19A | Membrane, cytoplasm, SK | RING | 2 |
| Q6ZMZ0 | RNF19B | Cytoplasmic granule membrane, ERM | RING | 2 |
| A6NCQ9 | RNF222 | Membrane | RING | 1 |
| E7ERA6 | RNF223 | Membrane | RING | 1 |
| Q96GF1 | RNF185 | MM, ERM | RING | 2 |
| M0QZC1 | RNF225 | Membrane | RING | 1 |
| Q9BY78 | RNF26 | ERM | RING | 5 |
| Q969K3 | RNF34 | PM, nucleus, cytoplasm, cytosol | RING | NA |
| Q9Y225 | RNF24 | GAM | RING | 1 |
| Q8TC41 | RNF217 | Membrane, cytoplasm | RING | 1 |
| Q5M7Z0 | RNFT1 | ERM | RING | 6 |
| Q96EX2 | RNFT2 | Membrane | RING | 4 |
| Q9HCE7 | SMURF1 | Cytoplasm, PM | HECTc | NA |
| A0AVI4 | TMEM129 | ERM | RING | 3 |
| Q9HAU4 | SMURF2 | Nucleus, cytoplasm, PM, membrane raft | HECTc | NA |
| O60858 | TRIM13 | ERM | RING | 1 |
| P36406 | TRIM23 | Cytoplasm, GAM, LM | RING | NA |
| Q86TM6 | SYVN1 | ERM | RING | 6 |
| Q8IWR1 | TRIM59 | ERM | RING | 1 |
| Q6ZMU5 | TRIM72 | PM, sarcolemma, VM | RING | NA |
| Q6ZT12 | UBR3 | Membrane | UBR | 3 |
| Q5T4S7 | UBR4 | Membrane | UBR | 2 |
| Q9H270 | VPS11 | EM, LM, VM, autophagosome | RING | NA |
| P49754 | VPS41 | EM, LM, GAM, VM, clathrin-coated vesicle | RING | NA |
| Q6PJI9 | WDR59 | LM | RING | NA |
| O95159 | ZFPL1 | GAM | RING | 1 |
| Q9H0M0 | WWP1 | Cytoplasm, PM, nucleus | HECTc | NA |
| Q8ND25 | ZNRF1 | VM | RING | NA |
| Q9ULT6 | ZNRF3 | PM | RING | 1 |
| Q8NHG8 | ZNRF2 | EM, LM, PM | RING | NA |
| Q8WWF5 | ZNRF4 | ERM | RING | 1 |
| Q9P253 | VPS18 | EM, LM, VM, autophagosome | RING | NA |
ERM, endoplasmic reticulum membrane; GAM, golgi apparatus membrane; PM, plasma membrane; VM, vesicle membrane; EM, endosome membrane; LM, lysosome membrane; MM, mitochondrion membrane; SK, cytoskeleton and microtubule.