Table 1.

Comparison of gasdermin protein expression, function, associated diseases and therapeutics in mice and humans.

Gasdermin genes		Protein expression pattern		Function		Disease association	Therapeutics targeting
Human	Mouse	Human	Mouse	Human	Mouse	Human	Drug	Indication
GSDMA	GsdmA1 GsdmA2 GsdmA3	Epithelial cells [bladder (2), gastrointestinal tract (4), skin (5)]	Epithelial cells [bladder (2), gastrointestinal tract (4), skin (5)]	Cell death	Cell death	Asthma (6) Systemic sclerosis (7)	–	–
GSDMB	None	Epithelial cells [gastrointestinal tract, bladder, airways, bone marrow, lymphoid tissues (4, 5)]	–	Pyroptosis	–	Asthma (8) Pro-tumoral activity (9)	–	–
GSDMC	GsdmC1 GsdmC2 GsdmC3 GsdmC4	Epithelial cells (4, 5) (skin, bladder, gastrointestinal tract, female tissues)	Epithelial cells (4, 5) (skin, bladder, gastrointestinal tract, female tissues)	Unknown	Unknown	No clear association	–	–
GSDMD	GsdmD	Leukocytes, respiratory system, gastrointestinal tract, bone marrow, liver, gallbladder (4, 5)	Leukocytes, respiratory system, gastrointestinal tract, bone marrow, liver, gallbladder (4, 5)	Pyroptosis	Pyroptosis	Hyper-activation in autoinflammatory diseases (CAPS, FMF) (10)	Dimethyl-fumarate (11) Disulfiram (12) α-NETA (13)	Hyper-inflammation Cancer
GSDME	GsdmE	Gastrointestinal tract, muscle tissues, genital tissues, endocrine tissues (4, 5)	Gastrointestinal tract, muscle tissues, genital tissues, endocrine tissues (4, 5)	Pyroptosis Anti-tumor activity	Pyroptosis Anti-tumor activity	Deafness (14) Tubulo- interstitial fibrosis (15) Cancer (16)	Disulfiram (12) Z-DEVD-FMK (15) miRNA combined with cetuximab (breast cancer) (17)	Hyper-inflammation Tubulo- interstitial fibrosis Cancer
PJVK	Pvjk	Transcript mainly expressed in male tissues and brain (4, 5)	Kidney, testis (4, 5)	Mitochondrial homeostasis Pexophagy (hypothesized)	Mitochondrial homeostasis Pexophagy (14)	Deafness (14)	–	–