1.1 Rate of exacerbations requiring systemic corticosteroids |
2 |
936 |
Rate Ratio (IV, Random, 95% CI) |
0.45 [0.36, 0.55] |
1.1.1 Eosinophilic |
2 |
936 |
Rate Ratio (IV, Random, 95% CI) |
0.45 [0.36, 0.55] |
1.2 At least one clinically significant exacerbation |
1 |
295 |
Odds Ratio (M‐H, Random, 95% CI) |
0.59 [0.37, 0.93] |
1.2.1 Eosinophilic |
1 |
295 |
Odds Ratio (M‐H, Random, 95% CI) |
0.59 [0.37, 0.93] |
1.3 Rate of exacerbations requiring admission |
2 |
936 |
Rate Ratio (IV, Random, 95% CI) |
0.31 [0.13, 0.73] |
1.3.1 Eosinophilic |
2 |
936 |
Rate Ratio (IV, Random, 95% CI) |
0.31 [0.13, 0.73] |
1.4 Rate of exacerbations requiring ED treatment or admission |
2 |
936 |
Rate Ratio (IV, Random, 95% CI) |
0.36 [0.20, 0.66] |
1.4.1 Eosinophilic |
2 |
936 |
Rate Ratio (IV, Random, 95% CI) |
0.36 [0.20, 0.66] |
1.5 Health‐related quality of life (ACQ) |
3 |
1231 |
Mean Difference (IV, Random, 95% CI) |
‐0.38 [‐0.50, ‐0.26] |
1.5.1 Eosinophilic |
3 |
1231 |
Mean Difference (IV, Random, 95% CI) |
‐0.38 [‐0.50, ‐0.26] |
1.6 Health‐related quality of life (SGRQ) |
3 |
1231 |
Mean Difference (IV, Random, 95% CI) |
‐6.37 [‐8.76, ‐3.98] |
1.6.1 Eosinophilic |
3 |
1231 |
Mean Difference (IV, Random, 95% CI) |
‐6.37 [‐8.76, ‐3.98] |
1.7 Pre‐bronchodilator FEV 1 (litres) |
3 |
1231 |
Mean Difference (IV, Random, 95% CI) |
0.09 [0.05, 0.14] |
1.7.1 Eosinophilic |
3 |
1231 |
Mean Difference (IV, Random, 95% CI) |
0.09 [0.05, 0.14] |
1.8 Serious adverse events |
3 |
1231 |
Risk Ratio (M‐H, Random, 95% CI) |
0.68 [0.46, 1.01] |
1.8.1 Eosinophilic |
3 |
1231 |
Risk Ratio (M‐H, Random, 95% CI) |
0.68 [0.46, 1.01] |
1.9 Adverse events leading to discontinuation |
3 |
1231 |
Risk Ratio (M‐H, Random, 95% CI) |
0.60 [0.19, 1.85] |
1.9.1 Eosinophilic |
3 |
1231 |
Risk Ratio (M‐H, Random, 95% CI) |
0.60 [0.19, 1.85] |