2.1 Rate of clinically significant exacerbations |
3 |
751 |
Rate Ratio (IV, Random, 95% CI) |
0.53 [0.44, 0.64] |
2.1.1 Eosinophilic |
3 |
751 |
Rate Ratio (IV, Random, 95% CI) |
0.53 [0.44, 0.64] |
2.2 Rate of exacerbations requiring emergency department treatment or admission |
2 |
690 |
Rate Ratio (IV, Random, 95% CI) |
0.52 [0.31, 0.87] |
2.2.1 Eosinophilic |
2 |
690 |
Rate Ratio (IV, Random, 95% CI) |
0.52 [0.31, 0.87] |
2.3 Rate of exacerbations requiring admission |
2 |
690 |
Rate Ratio (IV, Random, 95% CI) |
0.61 [0.33, 1.13] |
2.3.1 Eosinophilic |
2 |
690 |
Rate Ratio (IV, Random, 95% CI) |
0.61 [0.33, 1.13] |
2.4 People with one or more exacerbations |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Totals not selected |
2.4.1 Eosinophilic |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Totals not selected |
2.5 Health‐related quality of life (AQLQ) |
2 |
369 |
Mean Difference (IV, Random, 95% CI) |
0.21 [‐0.06, 0.47] |
2.5.1 Eosinophilic |
2 |
369 |
Mean Difference (IV, Random, 95% CI) |
0.21 [‐0.06, 0.47] |
2.6 Health‐related quality of life (ACQ) |
2 |
369 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.11 [‐0.32, 0.09] |
2.6.1 Eosinophilic |
2 |
369 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.11 [‐0.32, 0.09] |
2.7 Health‐related quality of life (SGRQ) |
1 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
2.7.1 Eosinophilic |
1 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
2.8 Pre‐bronchodilator FEV 1 (litres) |
2 |
690 |
Mean Difference (IV, Random, 95% CI) |
0.08 [0.02, 0.15] |
2.8.1 Eosinophilic |
2 |
690 |
Mean Difference (IV, Random, 95% CI) |
0.08 [0.02, 0.15] |
2.9 Serious adverse events |
3 |
751 |
Risk Ratio (M‐H, Random, 95% CI) |
0.59 [0.37, 0.94] |
2.9.1 Eosinophilic |
3 |
751 |
Risk Ratio (M‐H, Random, 95% CI) |
0.59 [0.37, 0.94] |
2.10 Adverse events leading to discontinuation |
3 |
751 |
Risk Ratio (M‐H, Random, 95% CI) |
0.72 [0.18, 2.92] |
2.10.1 Eosinophilic |
3 |
751 |
Risk Ratio (M‐H, Random, 95% CI) |
0.72 [0.18, 2.92] |
2.11 Blood eosinophil level (cells/μL) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
2.11.1 Eosinophilic |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |