Comparison 2. Mepolizumab (IV) versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Rate of clinically significant exacerbations	3	751	Rate Ratio (IV, Random, 95% CI)	0.53 [0.44, 0.64]
2.1.1 Eosinophilic	3	751	Rate Ratio (IV, Random, 95% CI)	0.53 [0.44, 0.64]
2.2 Rate of exacerbations requiring emergency department treatment or admission	2	690	Rate Ratio (IV, Random, 95% CI)	0.52 [0.31, 0.87]
2.2.1 Eosinophilic	2	690	Rate Ratio (IV, Random, 95% CI)	0.52 [0.31, 0.87]
2.3 Rate of exacerbations requiring admission	2	690	Rate Ratio (IV, Random, 95% CI)	0.61 [0.33, 1.13]
2.3.1 Eosinophilic	2	690	Rate Ratio (IV, Random, 95% CI)	0.61 [0.33, 1.13]
2.4 People with one or more exacerbations	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
2.4.1 Eosinophilic	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
2.5 Health‐related quality of life (AQLQ)	2	369	Mean Difference (IV, Random, 95% CI)	0.21 [‐0.06, 0.47]
2.5.1 Eosinophilic	2	369	Mean Difference (IV, Random, 95% CI)	0.21 [‐0.06, 0.47]
2.6 Health‐related quality of life (ACQ)	2	369	Mean Difference (IV, Fixed, 95% CI)	‐0.11 [‐0.32, 0.09]
2.6.1 Eosinophilic	2	369	Mean Difference (IV, Fixed, 95% CI)	‐0.11 [‐0.32, 0.09]
2.7 Health‐related quality of life (SGRQ)	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
2.7.1 Eosinophilic	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
2.8 Pre‐bronchodilator FEV 1 (litres)	2	690	Mean Difference (IV, Random, 95% CI)	0.08 [0.02, 0.15]
2.8.1 Eosinophilic	2	690	Mean Difference (IV, Random, 95% CI)	0.08 [0.02, 0.15]
2.9 Serious adverse events	3	751	Risk Ratio (M‐H, Random, 95% CI)	0.59 [0.37, 0.94]
2.9.1 Eosinophilic	3	751	Risk Ratio (M‐H, Random, 95% CI)	0.59 [0.37, 0.94]
2.10 Adverse events leading to discontinuation	3	751	Risk Ratio (M‐H, Random, 95% CI)	0.72 [0.18, 2.92]
2.10.1 Eosinophilic	3	751	Risk Ratio (M‐H, Random, 95% CI)	0.72 [0.18, 2.92]
2.11 Blood eosinophil level (cells/μL)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
2.11.1 Eosinophilic	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected