| 5.1 Rate of exacerbations requiring systemic corticosteroids |
4 |
3112 |
Rate Ratio (IV, Fixed, 95% CI) |
0.59 [0.52, 0.66] |
| 5.1.1 Eosinophilic |
4 |
2354 |
Rate Ratio (IV, Fixed, 95% CI) |
0.55 [0.48, 0.63] |
| 5.1.2 Non‐eosinophilic |
2 |
758 |
Rate Ratio (IV, Fixed, 95% CI) |
0.69 [0.56, 0.85] |
| 5.2 Rate of exacerbations requiring emergency department treatment or admission |
2 |
1537 |
Rate Ratio (IV, Fixed, 95% CI) |
0.68 [0.47, 0.98] |
| 5.2.1 Eosinophilic |
2 |
1537 |
Rate Ratio (IV, Fixed, 95% CI) |
0.68 [0.47, 0.98] |
| 5.3 Health‐related quality of life (AQLQ mean difference) |
3 |
1541 |
Mean Difference (IV, Fixed, 95% CI) |
0.23 [0.11, 0.35] |
| 5.3.1 Eosinophilic |
3 |
1541 |
Mean Difference (IV, Fixed, 95% CI) |
0.23 [0.11, 0.35] |
| 5.4 Health‐related quality of life (ACQ mean difference) |
4 |
2791 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.26 [‐0.34, ‐0.17] |
| 5.4.1 Eosinophilic |
4 |
2036 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.30 [‐0.40, ‐0.20] |
| 5.4.2 Non‐eosinophilic |
2 |
755 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.14 [‐0.30, 0.02] |
| 5.5 Health‐related quality of life (SGRQ mean difference) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 5.5.1 Eosinophilic |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 5.6 Pre‐bronchodilator FEV 1 (litres) |
4 |
2786 |
Mean Difference (IV, Fixed, 95% CI) |
0.11 [0.08, 0.15] |
| 5.6.1 Eosinophilic |
4 |
2048 |
Mean Difference (IV, Fixed, 95% CI) |
0.15 [0.11, 0.19] |
| 5.6.2 Non‐eosinophilic |
2 |
738 |
Mean Difference (IV, Fixed, 95% CI) |
0.03 [‐0.03, 0.10] |
| 5.7 Serious adverse events |
5 |
3304 |
Risk Ratio (M‐H, Random, 95% CI) |
0.76 [0.62, 0.93] |
| 5.7.1 Eosinophilic |
3 |
2193 |
Risk Ratio (M‐H, Random, 95% CI) |
0.72 [0.56, 0.93] |
| 5.7.2 Non‐eosinophilic |
2 |
758 |
Risk Ratio (M‐H, Random, 95% CI) |
0.85 [0.57, 1.27] |
| 5.7.3 Eosinophil status unknown |
2 |
353 |
Risk Ratio (M‐H, Random, 95% CI) |
0.75 [0.37, 1.51] |
| 5.8 Adverse events leading to discontinuation |
4 |
3253 |
Risk Ratio (M‐H, Random, 95% CI) |
2.04 [1.03, 4.03] |
| 5.8.1 Eosinophilic |
3 |
2193 |
Risk Ratio (M‐H, Random, 95% CI) |
2.26 [0.89, 5.73] |
| 5.8.2 Non‐eosinophilic |
2 |
758 |
Risk Ratio (M‐H, Random, 95% CI) |
1.81 [0.54, 6.05] |
| 5.8.3 Eosinophil status unknown |
1 |
302 |
Risk Ratio (M‐H, Random, 95% CI) |
1.82 [0.31, 10.69] |
| 5.9 Blood eosinophil level (% change from baseline) |
2 |
2295 |
Mean Difference (IV, Fixed, 95% CI) |
‐104.74 [‐116.12, ‐93.35] |
| 5.9.1 Eosinophilic |
2 |
1537 |
Mean Difference (IV, Fixed, 95% CI) |
‐101.74 [‐113.27, ‐90.21] |
| 5.9.2 Non‐eosinophilic |
2 |
758 |
Mean Difference (IV, Fixed, 95% CI) |
‐216.81 [‐287.35, ‐146.28] |
