Database/search platform/date of last search	Search strategy
Airways Register (via Cochrane Register of Studies) Date of most recent search: 7 February 2022	#1 AST:MISC1 #2 MeSH DESCRIPTOR Asthma Explode All #3 asthma*:ti,ab #4 #1 or #2 or #3 #5 MeSH DESCRIPTOR Antibodies, Monoclonal #6 MeSH DESCRIPTOR Antibodies, Monoclonal, Humanized #7 human* NEAR2 monoclonal* NEAR2 antibod* #8 mepolizumab #9 SB24056 or SB‐24056 #10 Bosatria or Nucala #11 benralizumab* #12 MEDI‐563 #13 reslizumab* #14 Cinquil or Cinqair #15 CEP‐38072 #16 "anti‐interleukin 5" #17 "anti‐IL5" #18 "anti‐IL‐5" #19 #5 or #6 or #7 or #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 #20 #4 AND #19
CENTRAL (via Cochrane Register of Studies) Date of most recent search: 7 February 2022	#1 AST:MISC1 #2 MeSH DESCRIPTOR Asthma Explode All #3 asthma*:ti,ab #4 #1 or #2 or #3 #5 MeSH DESCRIPTOR Antibodies, Monoclonal #6 MeSH DESCRIPTOR Antibodies, Monoclonal, Humanized #7 human* NEAR2 monoclonal* NEAR2 antibod* #8 mepolizumab #9 SB24056 or SB‐24056 #10 Bosatria or Nucala #11 benralizumab* #12 MEDI‐563 #13 reslizumab* #14 Cinquil or Cinqair #15 CEP‐38072 #16 "anti‐interleukin 5" #17 "anti‐IL5" #18 "anti‐IL‐5" #19 #5 or #6 or #7 or #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 #20 #4 AND #19
MEDLINE (Ovid) ALL Date of most recent search: 7 February 2022	1 exp asthma/ 2 asthma*.tw. 3 1 or 2 4 Antibodies, Monoclonal, Humanized/tu [Therapeutic Use] 5 mepolizumab.tw. 6 (Bosatria or Nucala).tw. 7 benralizumab.tw. 8 MEDI‐563.tw. 9 reslizumab.tw. 10 (Cinquil or Cinqair).tw. 11 CEP‐38072.tw. 12 "anti‐interleukin 5".tw. 13 "anti‐IL5".tw. 14 "anti‐IL‐5".tw. 15 or/4‐14 16 3 and 15 17 (controlled clinical trial or randomized controlled trial).pt. 18 (randomized or randomised).ab,ti. 19 placebo.ab,ti. 20 dt.fs. 21 randomly.ab,ti. 22 trial.ab,ti. 23 groups.ab,ti. 24 or/17‐23 25 Animals/ 26 Humans/ 27 25 not (25 and 26) 28 24 not 27 29 16 and 28
Embase (Ovid) Date of most recent search: 7 February 2022	1 exp asthma/ 2 asthma$.tw. 3 1 or 2 4 mepolizumab/ 5 mepolizumab.tw. 6 (Bosatria or Nucala).tw. 7 benralizumab.tw. 8 MEDI‐563.tw. 9 benralizumab/ 10 reslizumab/ 11 (Cinquil or Cinqair).tw. 12 CEP‐38072.tw. 13 "anti‐interleukin 5".tw. 14 "anti‐IL5".tw. 15 "anti‐IL‐5".tw. 16 or/4‐15 17 Randomized Controlled Trial/ 18 randomization/ 19 controlled clinical trial/ 20 Double Blind Procedure/ 21 Single Blind Procedure/ 22 Crossover Procedure/ 23 (clinica$ adj3 trial$).tw. 24 ((singl$ or doubl$ or trebl$ or tripl$) adj3 (mask$ or blind$ or method$)).tw. 25 exp Placebo/ 26 placebo$.ti,ab. 27 random$.ti,ab. 28 ((control$ or prospectiv$) adj3 (trial$ or method$ or stud$)).tw. 29 (crossover$ or cross‐over$).ti,ab. 30 or/17‐29 31 exp animals/ or exp invertebrate/ or animal experiment/ or animal model/ or animal tissue/ or animal cell/ or nonhuman/ 32 human/ or normal human/ or human cell/ 33 31 and 32 34 31 not 33 35 30 not 34 36 16 and 35
ClinicalTrials.gov Date of most recent search: 7 February 2022	Study type: interventional Condition: asthma Intervention: mepolizumab or reslizumab or benralizumab
WHO trials portal Date of most recent search: 7 February 2022	Condition: asthma Intervention: mepolizumab or reslizumab or benralizumab