FIGURE 2.

Molecular mechanisms induced by melatonin in different peripheral targets. Melatonin entrains the expression of clock genes in hepatocytes, reduces lipid accumulation, and decreases hepatic steatosis by downregulating Fas, Pparγ, and Srebp1 gene expression in the liver. The action of melatonin on white adipocytes induces a switch to the brown adipocyte phenotype, activating thermogenic action through stimulation of Ucp‐1, Irisin, and Pparγ gene expression. The lack of melatonin action in muscle cells induces a loss of the physiological rhythm of glucose. Illustrations created with BioRender.com