FIGURE 4.

Pathway analysis by KEGG of predicted target genes of downregulated (A) and upregulated (B) miRNAs in bovine trophoblast of MHC‐I heterozygous incompatible (n = 5) compared with control (n = 8) pregnancies, and predicted target genes of downregulated (C) and upregulated (D) miRNAs in bovine trophoblast of MHC‐I heterozygous incompatible (n = 5) compared with MHC‐I homozygous compatible (n = 9) pregnancies at day 35 of gestation. Control pregnancies were established by artificial insemination and MHC‐I heterozygous incompatible and homozygous compatible pregnancies were established by somatic cell nuclear transfer. Enrichment score [−log10(p‐value)] is a measure of how strongly the gene is associated with a specific biological process. KEGG, Kyoto Encyclopedia of Genes and Genomes; MHC‐I, major histocompatibility complex class I