TABLE 1.

Polymorphisms in the NR3C1 gene associated with glucocorticoid (GC) sensitivity

Polymorphism	GC sensitivity	Effects on body composition and metabolic profile	References
N363S	Increased	Increased LDL cholesterol levels in elderly, higher BMI, and hypertension	64 , 65 , 67 , 68
BclI	Increased	Increased insulin resistance, BMI, abdominal obesity, total body fat, and hypertension	64 , 71 , 72
9β	Decreased	Reduction in central obesity and a beneficial lipid profile	76
ER22/23EK	Decreased	Lower fasting insulin levels and LDL cholesterol concentrations. Sex‐specific beneficial body compositional changes	77 , 79

Abbreviations: BMI, body mass index; BMI, body mass index; LDL, low‐density lipoprotein; LDL, low‐density lipoprotein.