TABLE 4.
Moderator | k cohorts | % Between‐study heterogeneity explained | Estimate (slope) | 95% CI | Q m | P‐value | |
---|---|---|---|---|---|---|---|
HairF versus BMI | Mean age | 120 | 0.3 | 0.0006 | −0.0005; 0.0017 | 1.32 | 0.25 |
Mean BMI | 113 | 0.7 | 0.0003 | −0.0050; 0.0057 | 0.01 | 0.90 | |
Adults only | 84 | 0.7 | −0.0082 | −0.0180; 0.0016 | 2.70 | 0.10 | |
Mean HairF | 115 | 0.002 | 0.0000 | −0.0002; 0.0003 | 0.10 | 0.76 | |
LC–MS | 44 | 2.1 | 0.0008 | −0.0042; 0.0057 | 0.09 | 0.76 | |
CLIA | 23 | 7.4 | −0.0025 | −0.0092; 0.0041 | 0.55 | 0.46 | |
ELISA | 47 | 0.03 | 0.0000 | −0.0003; 0.0003 | 0.02 | 0.88 | |
% obesity | 57 | 11.9 | −0.0029 | −0.0049; −0.0010 | 8.95 | 0.0028 | |
% males | 122 | 2.5 | 0.0003 | −0.0006; 0.0011 | 0.38 | 0.54 | |
HairF versus BMI SDS | Mean age | 11 | 11.0 | 0.0127 | −0.0091; 0.0344 | 1.30 | 0.25 |
% males | 10 | 18.6 | 0.0037 | −0.0012; 0.0087 | 2.18 | 0.14 | |
Mean BMI SDS | 10 | 86.4 | −0.2108 | −0.3408; −0.0807 | 10.09 | 0.0015 | |
Mean HairF | 10 | 1.03 | −0.0006 | −0.0040; 0.0028 | 0.12 | 0.73 | |
HairF versus WC | Mean age | 23 | 21.9 | 0.0011 | −0.0007; 0.0028 | 1.46 | 0.23 |
Mean BMI | 20 | 9.3 | 0.0013 | −0.0081; 0.0106 | 0.07 | 0.79 | |
Adults only | 17 | 18.3 | −0.0080 | −0.0267; 0.0108 | 0.69 | 0.41 | |
Mean HairF | 21 | 0.002 | 0.0003 | −0.0006; 0.0012 | 0.46 | 0.50 | |
% obesity | 16 | 0.03 | −0.0002 | −0.0030; 0.0027 | 0.02 | 0.89 | |
% males | 23 | 39.5 | 0.0022 | 0.0010; 0.0033 | 14.29 | 0.0002 | |
HairF versus WHR | Mean age | 15 | 10.7 | 0.0024 | −0.0006; 0.0055 | 2.10 | 0.12 |
Mean BMI | 12 | 13.3 | −0.0120 | −0.0315; 0.0074 | 1.47 | 0.23 | |
Adults only | 10 | 54.4 | −0.0170 | −0.0377; 0.0037 | 2.59 | 0.11 | |
Mean HairF | 14 | 4.0 | 0.0014 | −0.0020; 0.0047 | 0.65 | 0.42 | |
LC–MS | 11 | 25.2 | 0.0056 | −0.0013; 0.0126 | 2.53 | 0.11 | |
% males | 15 | 28.7 | 0.0011 | 0.0001; 0.0021 | 5.07 | 0.02 | |
HairE versus BMI | Mean age | 15 | 27.9 | 0.0016 | −0.0004; 0.0035 | 2.56 | 0.11 |
Mean BMI | 12 | 47.2 | 0.0096 | −0.0006; 0.0197 | 3.41 | 0.07 | |
Mean HairE | 13 | 65.2 | 0.0046 | 0.0025; 0.0068 | 17.96 | <.0001 | |
% males | 15 | 12.2 | 0.0010 | −0.0010; 0.0030 | 0.99 | 0.32 |
Note: Meta‐regressions were only performed when data of at least 10 cohorts were available. Bold text indicates statistically significant effect (P‐value < 0.05).
Abbreviations: CI, confidence interval; Qm, Cochrane's Q for the moderator; HairF, hair cortisol; SDS, standard deviation score; WC, waist circumference; WHR, waist‐to‐hip ratio; LC–MS, liquid chromatography‐(tandem) mass spectrometry; ELISA, enzyme‐linked immunosorbent assay; CLIA, chemiluminescent immunoassay; NA, not available or not applicable.