FIGURE 1.

Blockade of laminin alpha-3 alters the keratinocyte transcriptome. Primary human keratinocytes were incubated with laminin alpha-3 blocking antibody (clone: P3H9-2) or Isotype control (n=3/condition). RNA-seq was subsequently performed. Fold change ≥2 and FDR <0.05 were set as screening criteria. A) Select differentially expressed epithelial genes are shown as a heat map, revealing upregulation of desmosomal genes and downregulation of hemidesmosomal genes. B) Gene ontology for biologic processes of all significantly differentially expressed genes reveals marked enrichment of epidermal genes