TABLE I.
Patient characteristics
| Characteristic | Infant AD (n = 17) |
Infant controls (n = 13) |
P value |
Child AD (n = 10) |
Child controls (n = 13) |
P value |
Adolescent AD (n = 14) |
Adolescent controls (n = 5) |
P value |
Adult AD (n = 13) |
Adult controls (n = 15) |
P value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age (y), mean ± SD | 1.2 ± 1.2 | 1.2 ± 0.8 | 0.9 | 7.8 ± 2.1 | 7.9 ± 2.3 | 0.94 | 14.8 ± 1.7 | 14.2 ± 1.8 | 0.5 | 45.2 ± 14.6 | 35.6 ± 10.0 | 0.06 |
| Female sex, n (%) | 8 (47.0) | 7 (53.8) | >.99 | 6 (60.0) | 7 (53.8) | >.99 | 6 (42.8) | 3 (60.0) | 0.6 | 7 ± 53.8 | 8 ± 53.3 | >.99 |
| Clinical severity measures | ||||||||||||
| SCORAD, mean ± SD | 58.1 ± 12.4 | NA | NA | 64.3 ± 15.7 | NA | NA | 62.1 ± 20.0 | NA | NA | 65.1 ± 13.3 | NA | NA |
| EASI, mean ± SD | 15.3 ± 8.8 | NA | NA | 19.8 ± 12.6 | NA | NA | 27.4 ± 22.8 | NA | NA | NA | NA | NA |
| TEWL, lesional (g/h/m2), mean ± SD | 32.9 ± 13.8 | NA | NA | 36.8 ± 17.6 | NA | NA | 51.2 ± 25.9 | NA | NA | NA | NA | NA |
| TEWL, nonlesional (g/h/m2), mean ± SD | 16.2 ± 8.0 | NA | NA | 25.6 ± 10.5 | NA | NA | 25.6 ± 13.5 | NA | NA | NA | NA | NA |
| Pruritus ADQ, mean ± SD | 17.2 ± 9.3 | NA | NA | 26.8 ± 5.5 | NA | NA | 22.0 ± 9.4 | NA | NA | NA | NA | NA |
| IgE (IU/mL), mean ± SD | 5830.6 ± 858.3 | NA | NA | 1072 ± 915.8 | NA | NA | 6136 ± 5943.6 | NA | NA | 230 ± 291.0 | NA | NA |
ADQ, Atopic Dermatitis Quickscore; EASI, Eczema Area and Severity Index; NA, not applicable/available; TEWL, transepidermal water loss