Figure 1.

Molecular mechanisms of the LC3‐associated phagocytosis (LAP) pathway. Engulfment of pathogens, dying cells, or antibody‐coated particles via TLR, PtdSer, and FcR, respectively, triggers recruitment of the RUBCN‐containing Class III PI3K complex to the cargo‐containing phagosome. RUBCN also binds and stabilizes the NOX2 complex. RUBCN activity is required for recruitment of the downstream ubiquitin‐like conjugation systems to generate LC3‐II and localize it to the cargo‐containing phagosome to form the LAPosome.