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Chemical structure of first, second, and third generation ASOs, compared to DNA and RNA structures, followed with examples of FDA‐approved drugs. 2′‐MOE, 2′‐O‐methoxyethyl; 2′‐OME, 2‐O‐methyl; ASOs, antisense oligonucleotides; DNA, deoxyribonucleotidic acid; LNA, locked nucleic acid; MF, morpholino phosphorodiamidate; PMO, phosphorodiamidate morpholino oligomer; PNA, peptide nucleic acid; PS, phosphorothioate; RNA, ribonucleotidic acid
