FIGURE 1.

Adaptations to the dynamic contrast‐enhanced (DCE) simulation tool: (A) whereas in the original tool five vessels are simulated with a certain permeability and contrast agent (CA) is leaking into the surrounding extracellular extravascular space, in our model (B) the “vessels” represent the red blood cells with zero permeability, while the extracellular extravascular space corresponds to the blood plasma. (C) Linearly increasing [CA], resulting in phase and magnitude changes and dephasing, which were finally summed over the simulated space, thereby inducing more dephasing for gradient‐echo sequences