TABLE 1.
Definitions of initial treatment
Initial treatment category | Definitions |
---|---|
A. Surgery | Surgery for SCLC at any time point (regardless of any other treatment received) |
B. Radiotherapy alone | Radiotherapy + no SACT nor surgery within 90 days (3 months) after radiotherapy |
C. SACT + radiotherapy | Sum of C1, C2, C3 and C4 |
C1. Radiotherapy followed by SACT | Radiotherapy + identification of SACT within 90 days (3 months) after 1st radiotherapy regimen + no surgery |
C2. SACT followed by radiotherapy | SACT + identification of radiotherapy within 42 days (6 weeks) after start of last SACT cycle + no surgery |
C3. Induction chemoradiotherapy | SACT + radiotherapy within less than 54 days (9 weeks/~3 cycles) of SACT initiation + no surgery |
C4. Non‐induction chemoradiotherapy | SACT + radiotherapy starting at least 54 days (9 weeks/~3 cycles) after SACT initiation but before the end of the start of the last SACT cycle + no surgery |
D. SACT alone | SACT + no radiotherapy nor surgery within 150 days (5 months) of 1st SACT regimen start |
E. Not treated | No SACT, surgery or radiotherapy identified over entire follow‐up period |
Note: Initial treatment was defined as the first treatment received within 3 months of diagnosis, associated with any other treatment received within a time period following first treatment as described above.
Abbreviations: SACT, systemic anticancer therapy; SCLC, small cell lung cancer.