Figure 5.

Uptake of a DNA icosahedral nanostructure in C. elegans. Top: schematic representing the structure of the DNA icosahedron and encapsulation of FD10 molecules within the structure (I_FD10). Bottom: representative image of a C. elegans wild‐type specimen injected with free FD10 (upper image) and I_FD10 (lower image). It can be seen that the I_FD10 accumulated primarily in the coelomocytes unlike the even distribution throughout the organism in case of free FD10 molecules. Schematic showing the two pathways of endocytosis taken by free FD10 versus I_FD10, respectively. EE, early endosome; LE, late endosome; Ly, lysosome; SV, spherical vesicle. Reproduced with permission.[[qv: 75a]] Copyright 2011, Springer Nature.