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Native positive ion mass spectra of “empty” (blue profile) and “filled” (red profile) AAV8 VLPs. The “empty” VLPs preparation shows a dominant peak e assigned to monomeric “empty” capsids. The “filled” VLPs preparation contains the shared peak e and a second peak f assigned to “filled” capsids. The figure comprises (A) the entire m/z range and the magnification of the range for (B) peak e and (C) peak f
