TABLE 3.
Comparative reduction in mPASI and in the achievement of PASI 100, 90, 75, and <3 in the subpopulation analyzed (obese vs. non‐obese, PSA vs. non‐PSA, previous biologic status, difficult‐site involvement and smoking habits) during weeks 16, 28, and 40
| BMI ≥ 30 | BMI < 30 | p‐value | PSA | Non PSA | p‐value | Bio‐Experienced | Bio‐naive | p‐value | Difficult‐site | Non difficult‐site | p‐value | Smokers | Ex‐Smokers | Non‐Smokers | p‐value | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| mPASI T0 | 12.3 | 12.5 | 0.259 | 12.5 | 12.6 | 0.791 | 12.1 | 13.1 | 0.106 | 12.6 | 12.5 | 0.855 | 12.0 | 12.9 | 12.8 | 0.861 | |||||||||||
| mPASI 16 W | 2.2 | 1.8 | 0.101 | 2.7 | 1.7 | 0.036 | 2.3 | 1.3 | 0.047 | 1.8 | 1.6 | 0.101 | 1.9 | 2.6 | 1.4 | 0.050 | |||||||||||
| PASI 100 16 W | 8/35 | 28% | 43/129 | 34% | 0.258 | 6/22 | 27% | 45/142 | 32% | 0.677 | 27/95 | 28% | 24/69 | 35% | 0.385 | 33/119 | 28% | 18/45 | 41% | 0.130 | 15/63 | 24% | 11/39 | 28% | 25/62 | 40% | 0.124 |
| PASI 90 16 W | 12/35 | 40% | 73/129 | 56% | 0.088 | 8/22 | 36% | 79/142 | 56% | 0.092 | 42/95 | 44% | 45/69 | 65% | 0.007 | 56/119 | 47% | 31/45 | 69% | 0.012 | 32/63 | 51% | 16/39 | 41% | 39/62 | 63% | 0.090 |
| PASI 75 16 W | 24/35 | 66% | 96/129 | 75% | 0.505 | 11/22 | 50% | 109/142 | 77% | 0.008 | 63/95 | 66% | 57/69 | 83% | 0.020 | 84/119 | 71% | 36/45 | 80% | 0.225 | 45/63 | 71% | 24/39 | 62% | 51/62 | 82% | 0.067 |
| PASI <3 16 W | 21/35 | 60% | 96/129 | 74% | 0.122 | 13/22 | 59% | 103/142 | 73% | 0.197 | 65/95 | 68% | 51/69 | 74% | 0.445 | 80/119 | 67% | 36/45 | 80% | 0.109 | 43/63 | 68% | 24/39 | 62% | 49/62 | 79% | 0.146 |
| mPASI 28 W | 1.7 | 0.9 | 0.006 | 1.9 | 0.9 | 0 0.006 | 1.5 | 0.5 | 0.175 | 1.2 | 0.8 | 0.260 | 1.1 | 1.3 | 0.9 | 0.497 | |||||||||||
| PASI 100 28 W | 4/18 | 22% | 48/84 | 58% | 0.007 | 4/16 | 25% | 48/86 | 56% | 0.024 | 29/60 | 48% | 23/42 | 55% | 0.523 | 37/77 | 48% | 15/25 | 60% | 0.299 | 20/42 | 48% | 11/24 | 46% | 21/36 | 58% | 0.542 |
| PASI 90 28 W | 12/18 | 67% | 61/84 | 72% | 0.611 | 8/16 | 50% | 65/86 | 76% | 0.037 | 37/60 | 62% | 36/42 | 86% | 0.008 | 53/77 | 69% | 20/25 | 80% | 0.282 | 29/42 | 69% | 15/24 | 63% | 29/36 | 81% | 0.282 |
| PASI 75 28 W | 15/18 | 83% | 73/84 | 87% | 0.689 | 12/16 | 75% | 76/86 | 88% | 0.154 | 48/60 | 80% | 40/42 | 95% | 0.028 | 66/77 | 86% | 22/25 | 88% | 0.773 | 35/42 | 83% | 21/24 | 88% | 32/36 | 89% | 0.761 |
| PASI <3 28 W | 14/18 | 78% | 75/84 | 89% | 0.184 | 11/16 | 69% | 78/86 | 91% | 0.016 | 49/60 | 82% | 40/42 | 95% | 0.043 | 66/77 | 86% | 23/25 | 92% | 0.413 | 36/42 | 86% | 20/24 | 83% | 33/36 | 92% | 0.591 |
| mPASI 40 W | 3.3 | 0.6 | 0.059 | 4.1 | 0.5 | 0.016 | 1.6 | 0.3 | 0.114 | 1.6 | 0.5 | 0.184 | 2.7 | 1 | 0.5 | 0.029ª | |||||||||||
| PASI 100 40 W | 1/8 | 13% | 15/22 | 68% | 0.007 | 0/6 | 0% | 16/24 | 67% | 0.003 | 10/22 | 45% | 6/8 | 75% | 0.151 | 9/21 | 43% | 7/9 | 78% | 0.079 | 3/10 | 30% | 3/8 | 38% | 10/12 | 83% | 0.026ª |
| PASI 90 40 W | 4/8 | 50% | 18/22 | 82% | 0.081 | 1/6 | 17% | 21/24 | 88% | 0.000 | 14/22 | 64% | 8/8 | 100% | 0.046 | 15/21 | 71% | 7/9 | 78% | 0.719 | 5/10 | 50% | 6/8 | 75% | 11/12 | 92% | 0.088 |
| PASI 75 40 W | 5/8 | 63% | 20/22 | 91% | 0.065 | 3/6 | 50% | 22/24 | 92% | 0.014 | 17/22 | 77% | 8/8 | 100% | 0.140 | 18/21 | 86% | 7/9 | 78% | 0.593 | 7/10 | 70% | 7/8 | 88% | 11/12 | 92% | 0.372 |
| PASI <3 40 W | 5/8 | 63% | 21/22 | 95% | 0.019 | 3/6 | 50% | 23/24 | 96% | 0.003 | 18/22 | 82% | 8/8 | 100% | 0.195 | 18/21 | 86% | 8/9 | 89% | 0.815 | 7/10 | 70% | 7/8 | 88% | 12/12 | 100% | 0.119 |
Abbreviations: BMI, body max index; mPASI, mean Psoriasis area severity index. a Smokers versus non‐smokers. Bold values are p<0.05.