Table 3.
Cause of death among patients diagnosed with prostate cancer between 1975 and 2016 in SEER 18 registries by time from cancer diagnosis.
| Cause of death | Time from cancer diagnosis | |||||||
|---|---|---|---|---|---|---|---|---|
| 1 years | 1-5 years | 5-10 years | 10+ years | |||||
| No. of observed deaths (%) | SMR (95% CI) | No. of observed deaths (%) | SMR (95% CI) | No. of observed deaths (%) | SMR (95% CI) | No. of observed deaths (%) | SMR (95% CI) | |
| All causes of death | 51,372 (100.0%) | NA | 164,555 (100.0%) | NA | 144,956 (100.0%) | NA | 140,379 (100.0%) | NA |
| Prostate cancer | 22,062 (42.9%) | NA | 58,887 (35.8%) | NA | 33,391 (23.0%) | NA | 22,848 (16.3%) | NA |
| Other cancers | 4,905 (9.5%) | NA | 24,552 (14.9%) | NA | 25,475 (17.6%) | NA | 23,404 (16.7%) | NA |
| Non-cancer causes | 24,405 (47.5%) | 0.95 (0.94-0.96) | 81,116 (49.3%) | 0.98 (0.97-0.98) | 86,090 (59.4%) | 1.53 (1.52-1.54) | 94,127 (67.1%) | 2.98 (2.96-3.00) |
| Infectious | 1,696 (3.3%) | 0.98 (0.93-1.02) | 5,743 (3.5%) | 1.04 (1.02-1.07) | 5,811 (4.0%) | 1.62 (1.58-1.66) | 6,112 (4.4%) | 3.26 (3.18-3.35) |
| Pneumonia and Influenza | 1,047 (2.0%) | 1.00 (0.94-1.07) | 3,677 (2.2%) | 1.14 (1.11-1.18) | 3,740 (2.6%) | 1.86 (1.80-1.92) | 3,946 (2.8%) | 3.80 (3.68-3.92) |
| Tuberculosis | 25 (0.0%) | 1.14 (0.77-1.68) | 41 (0.0%) | 0.57 (0.42-0.77) | 32 (0.0%) | 0.61 (0.43-0.86) | 28 (0.0%) | 0.75 (0.52-1.09) |
| Septicemia | 405 (0.8%) | 0.98 (0.89-1.08) | 1,328 (0.8%) | 0.99 (0.94-1.05) | 1,377 (0.9%) | 1.56 (1.48-1.64) | 1,425 (1.0%) | 3.43 (3.26-3.61) |
| Other infectious and parasitic diseases including HIV | 219 (0.4%) | 0.85 (0.75-0.97) | 697 (0.4%) | 0.79 (0.73-0.85) | 662 (0.5%) | 1.03 (0.95-1.11) | 713 (0.5%) | 1.87 (1.74-2.01) |
| Cardiovascular diseases | 14,715 (28.6%) | 1.03 (1.01-1.04) | 45,385 (27.6%) | 0.98 (0.97-0.99) | 45,148 (31.1%) | 1.42 (1.40-1.43) | 46,307 (33.0%) | 2.46 (2.44-2.48) |
| Diseases of heart | 11,676 (22.7%) | 1.03 (1.01-1.05) | 35,602 (21.6%) | 0.97 (0.96-0.98) | 34,896 (24.1%) | 1.37 (1.35-1.38) | 35,683 (25.4%) | 2.32 (2.29-2.34) |
| Hypertension without heart disease | 273 (0.5%) | 1.08 (0.96-1.22) | 988 (0.6%) | 1.25 (1.17-1.33) | 1,212 (0.8%) | 2.45 (2.32-2.59) | 1,443 (1.0%) | 6.48 (6.16-6.83) |
| Cerebrovascular diseases | 2,082 (4.1%) | 0.99 (0.94-1.03) | 6,821 (4.1%) | 1.02 (1.00-1.04) | 7,240 (5.0%) | 1.64 (1.60-1.68) | 7,373 (5.3%) | 3.12 (3.05-3.20) |
| Atherosclerosis | 273 (0.5%) | 1.28 (1.13-1.44) | 756 (0.5%) | 1.19 (1.11-1.28) | 692 (0.5%) | 1.80 (1.67-1.93) | 686 (0.5%) | 3.39 (3.15-3.65) |
| Aortic aneurysm and dissection | 280 (0.5%) | 0.94 (0.83-1.05) | 813 (0.5%) | 0.80 (0.75-0.86) | 704 (0.5%) | 0.93 (0.87-1.01) | 628 (0.4%) | 1.30 (1.20-1.41) |
| Other diseases of arteries, arterioles, capillaries | 131 (0.3%) | 0.91 (0.77-1.08) | 405 (0.2%) | 0.87 (0.79-0.96) | 404 (0.3%) | 1.26 (1.15-1.39) | 494 (0.4%) | 2.72 (2.49-2.97) |
| Respiratory diseases | 1,682 (3.3%) | 0.83 (0.79-0.87) | 6,333 (3.8%) | 0.94 (0.92-0.97) | 6,679 (4.6%) | 1.44 (1.40-1.47) | 6,500 (4.6%) | 2.58 (2.52-2.64) |
| Chronic obstructive pulmonary disease and allied cond |
1,682 (3.3%) | 0.83 (0.79-0.87) | 6,333 (3.8%) | 0.94 (0.92-0.97) | 6,679 (4.6%) | 1.44 (1.40-1.47) | 6,500 (4.6%) | 2.58 (2.52-2.64) |
| Gastrointestinal diseases | 329 (0.6%) | 0.71 (0.64-0.79) | 1,155 (0.7%) | 0.72 (0.68-0.76) | 856 (0.6%) | 0.71 (0.66-0.76) | 707 (0.5%) | 0.86 (0.80-0.92) |
| Stomach and duodenal ulcers | 107 (0.2%) | 1.42 (1.18-1.72) | 279 (0.2%) | 1.14 (1.01-1.28) | 231 (0.2%) | 1.36 (1.19-1.54) | 204 (0.1%) | 1.88 (1.64-2.16) |
| Chronic liver disease and cirrhosis | 222 (0.4%) | 0.57 (0.50-0.65) | 876 (0.5%) | 0.64 (0.60-0.69) | 625 (0.4%) | 0.60 (0.56-0.65) | 503 (0.4%) | 0.70 (0.64-0.77) |
| Renal diseases | 461 (0.9%) | 0.79 (0.73-0.87) | 1,673 (1.0%) | 0.91 (0.87-0.96) | 2,052 (1.4%) | 1.75 (1.68-1.83) | 2,436 (1.7%) | 4.73 (4.54-4.92) |
| Nephritis, nephrotic syndrome and nephrosis | 461 (0.9%) | 0.79 (0.73-0.87) | 1,673 (1.0%) | 0.91 (0.87-0.96) | 2,052 (1.4%) | 1.75 (1.68-1.83) | 2,436 (1.7%) | 4.73 (4.54-4.92) |
| External injuries | 1,139 (2.2%) | 0.94 (0.89-1.00) | 3,884 (2.4%) | 0.97 (0.94-1.00) | 3,695 (2.5%) | 1.31 (1.27-1.35) | 3,584 (2.6%) | 2.14 (2.07-2.21) |
| Accidents and adverse effects | 708 (1.4%) | 0.82 (0.76-0.88) | 2,724 (1.7%) | 0.96 (0.92-0.99) | 2,688 (1.9%) | 1.38 (1.33-1.43) | 2,870 (2.0%) | 2.61 (2.52-2.71) |
| Suicide and self-Inflicted injury | 382 (0.7%) | 1.35 (1.22-1.49) | 1,054 (0.6%) | 1.08 (1.01-1.14) | 931 (0.6%) | 1.29 (1.21-1.37) | 675 (0.5%) | 1.46 (1.35-1.57) |
| Homicide and legal intervention | 49 (0.1%) | 0.91 (0.69-1.20) | 106 (0.1%) | 0.56 (0.46-0.67) | 76 (0.1%) | 0.50 (0.40-0.63) | 39 (0.0%) | 0.34 (0.25-0.47) |
| Other non-cancer causes | 4,383 (8.5%) | 0.82 (0.80-0.85) | 16,943 (10.3%) | 1.01 (0.99-1.02) | 21,849 (15.1%) | 2.01 (1.99-2.04) | 28,481 (20.3%) | 5.32 (5.26-5.38) |
| Diabetes mellitus | 757 (1.5%) | 0.77 (0.72-0.83) | 2,810 (1.7%) | 0.86 (0.82-0.89) | 3,086 (2.1%) | 1.33 (1.28-1.38) | 3,088 (2.2%) | 2.48 (2.40-2.57) |
| Alzheimers | 311 (0.6%) | 0.69 (0.62-0.77) | 1,754 (1.1%) | 1.33 (1.27-1.39) | 3,233 (2.2%) | 4.53 (4.38-4.69) | 5,336 (3.8%) | 23.49 (22.87-24.13) |
| Congenital anomalies | 32 (0.1%) | 1.04 (0.74-1.47) | 82 (0.0%) | 0.78 (0.63-0.97) | 87 (0.1%) | 1.11 (0.90-1.37) | 88 (0.1%) | 1.74 (1.41-2.14) |
| Symptoms, signs and ill-defined conditions | 210 (0.4%) | 0.72 (0.63-0.82) | 858 (0.5%) | 0.93 (0.87-1.00) | 908 (0.6%) | 1.51 (1.41-1.61) | 1,162 (0.8%) | 3.40 (3.21-3.60) |
| Other cause of death | 3,073 (6.0%) | 0.86 (0.83-0.89) | 11,439 (7.0%) | 1.02 (1.00-1.04) | 14,535 (10.0%) | 2.03 (2.00-2.07) | 18,807 (13.4%) | 5.39 (5.31-5.46) |
NA, Not Applicable.