FIGURE 3.

Inhibition of the EP₁ receptor reduces UUO‐induced protein expression of fibrotic markers. Mice were subject to 7 days of UUO and treated with SC‐19220 (25 mg/kg) via IP injection, followed by Western Blot analysis of fibrotic markers (A) fibronectin (FN) and (B) alpha‐smooth muscle actin (αSMA) (n = 10). Data are presented as means ± SEM; *P < .05, **P < .01 and ***P < .001. (C) Representative immunohistochemistry images of FN (upper) and αSMA (lower) expression, 20× magnification, scale bar is 50 μm. n = 4