TABLE 3.
All Individuals | Boys | Girls | |||||||
---|---|---|---|---|---|---|---|---|---|
Metabolite variables | m/z | Retention time (min) | p‐value | Corrected p‐value | Fold change | p‐value | Fold change | p‐value | Fold change |
LysoPS(22:2) | 578.3481 | 0.49 | 5.99 × 10−06 a , b | 2.16 × 10−05 a , b | 1.48 | 4.95 × 10−05 | 1.58 | 0.021 | 1.37 |
Unkown | 1015.6761 | 0.39 a , b | 2.28 × 10−05 a , b | 3.79 × 10−05 a , b | 1.57 | 0.0002 | 1.64 | 0.033 | 1.49 |
Dimethylarginine | 203.0533 | 0.33 | 0.0001 b | 0.0002 b | 1.85 | 0.0001 | 2.20 | 0.074 | 1.50 |
C24H30O8 | 447.2815 | 0.47 | 0.0002 b | 0.0003 b | 1.65 | 0.0009 | 1.80 | 0.032 | 1.49 |
C13 isotope of C30H40O8 | 530.3357 | 0.52 | 0.0003 b | 0.0003 b | 1.31 | 0.0069 | 1.26 | 0.016 | 1.36 |
C27H38O9 | 507.3104 | 0.50 | 0.0004 b | 0.0007 b | 1.31 | 0.0015 | 1.36 | 0.072 | 1.26 |
Unknown | 431.2617 | 0.39 | 0.0005 b | 0.0007 b | 1.38 | 0.0003 | 1.50 | 0.104 | 1.26 |
LysoPE(20:1) | 508.3468 | 0.66 | 0.0008 b | 0.0005 b | 1.09 | 0.0053 | 1.08 | 0.059 | 1.09 |
Unknown | 590.3393 | 0.47 | 0.0018 | 0.0017 | 1.48 | 0.0063 | 1.49 | 0.052 | 1.47 |
LysoPG(16:0) | 486.2760 | 0.54 | 0.0022 | 0.0026 | 1.14 | 0.0240 | 1.11 | 0.054 | 1.17 |
C30H40O8 | 529.3246 | 0.47 | 0.0034 | 0.0034 | 1.60 | 0.0075 | 1.73 | 0.114 | 1.46 |
LysoPA(22:1) | 495.3132 | 0.86 | 0.0040 | 0.0051 | 1.41 | 0.0122 | 1.42 | 0.101 | 1.39 |
Unknown | 200.8896 | 0.319 | 0.0043 | 0.0031 | 0.91 | 0.0066 | 0.91 | 0.069 | 0.90 |
Unknown | 162.9649 | 0.367 | 0.0046 | 0.0075 | 2.03 | 0.0021 | 2.76 | 0.418 | 1.29 |
Unknown | 222.8750 | 0.38 | 0.0050 | 0.0022 | 0.87 | 0.1124 | 0.95 | 0.006 | 0.79 |
Note: ‘p‐value’ are the unadjusted p‐values. ‘Corrected p‐values’ have been adjusted for sex, birth weight and feeding type. All p‐values were calculated using generalized linear models comparing high and low tertiles of trunk: peripheral ratio. Fold change is calculated relative to the ‘low’ group. Putative annotations: C24H30O8 – Esterone Glucoronide, C27H38O9 –Hydroxyprogesterone Glucoronide, C30H40O8 – Hydroxypentaoxolanostenoic acid.
Abbreviations: LysoPA, lysophosphosphatidic acid; LysoPE, lysophosphatidylethanolamine; LysoPG, lysophosphatidylglycerol; LysoPS, lysophosphatidylserine; m/z, mass‐to‐charge ratio.
Passing FDR based on Bonferoni.
Passing FDR based on Benjamini‐Hochberg.