Table 1.
HDL lipids significantly modified after VOO intervention versus its baseline
| Lipid | Log fold change | p‐value | p‐value adjusted by FDR |
|---|---|---|---|
| LC‐FA combination composition | |||
| TAG(FA18:1) | 0.0940763 | 0.0001126 | 0.0124762 |
| SM(FA22:1) | 0.1038876 | 0.0001543 | 0.0124762 |
| CE(FA22:6) | −0.2134798 | 0.0002163 | 0.0124762 |
| PC(FA18:1) | 0.1147135 | 0.0013702 | 0.0538892 |
| TAG(FA18:2) | −0.1862806 | 0.0015575 | 0.0538892 |
| SM(FA26:0) | −0.1462294 | 0.0026301 | 0.0703188 |
| CE(FA18:1) | 0.0616907 | 0.0029727 | 0.0703188 |
| TAG(FA20:1) | 0.1643749 | 0.0032517 | 0.0703188 |
| Lipid species concentration | |||
| TAG56:8(FA18:2) | −0.4777177 | 0.0000352 | 0.0270411 |
| PC(FA18:1/FA18:1) | 0.3392268 | 0.0001713 | 0.0658497 |
| TAG51:4(FA18:2) | −0.3454150 | 0.0004444 | 0.0867678 |
| TAG51:5(FA18:3) | −0.7895801 | 0.0004843 | 0.0867678 |
| TAG54:7(FA22:5) | −0.7164132 | 0.0005642 | 0.0867678 |
| Lipid species composition | |||
| TAG56:5(FA20:3) | 0.2616832 | 0.0000099 | 0.0043817 |
| TAG51:4(FA18:2) | −0.3755527 | 0.0000126 | 0.0043817 |
| TAG51:4(FA15:0) | −0.3697035 | 0.0000171 | 0.0043817 |
| TAG54:2(FA20:1) | 0.2707045 | 0.0000334 | 0.0064200 |
| TAG52:2(FA16:0) | 0.1733400 | 0.0000996 | 0.0135271 |
| TAG52:2(FA18:1) | 0.1893192 | 0.0001055 | 0.0135271 |
| PC(FA18:1/FA18:1) | 0.2851526 | 0.0001326 | 0.0145688 |
| SM(FA22:1) | 0.1038876 | 0.0001543 | 0.0148317 |
| TAG54:7(FA22:5) | −0.8269101 | 0.0002159 | 0.0166373 |
| CE(FA22:6) | −0.2134798 | 0.0002163 | 0.0166373 |
| TAG56:8(FA18:2) | −0.5077355 | 0.0003964 | 0.0277134 |
| TAG51:5(FA18:3) | −0.9335297 | 0.0005247 | 0.0336250 |
| TAG54:2(FA18:1) | 0.1971140 | 0.0005983 | 0.0353917 |
| TAG56:4(FA20:2) | 0.2516185 | 0.0006653 | 0.0365420 |
| TAG54:4(FA20:3) | 0.1716807 | 0.0007294 | 0.0373921 |
| TAG56:4(FA20:3) | 0.1471088 | 0.0008224 | 0.0395282 |
| TAG50:4(FA18:2) | −0.3485138 | 0.0008820 | 0.0398996 |
| TAG52:4(FA18:2) | −0.3113580 | 0.0010850 | 0.0441748 |
| TAG52:4(FA16:0) | −0.3070039 | 0.0011523 | 0.0441748 |
| TAG53:3(FA18:2) | −0.1628848 | 0.0011950 | 0.0441748 |
| TAG50:3(FA14:1) | 0.2673740 | 0.0012636 | 0.0441748 |
| TAG52:1(FA18:1) | 0.1685961 | 0.0012638 | 0.0441748 |
| TAG54:2(FA16:0) | 0.1873376 | 0.0013449 | 0.0449658 |
| TAG54:3(FA20:2) | 0.1731868 | 0.0014159 | 0.0453672 |
| TAG54:3(FA18:1) | 0.2509162 | 0.0019271 | 0.0574393 |
| TAG54:8(FA18:2) | −0.8899613 | 0.0019420 | 0.0574393 |
| TAG51:3(FA18:2) | −0.1743374 | 0.0023050 | 0.0648026 |
| TAG51:3(FA15:0) | −0.1886565 | 0.0023595 | 0.0648026 |
| TAG54:2(FA18:0) | 0.1473225 | 0.0024488 | 0.0649346 |
| SM(FA26:0) | −0.1462308 | 0.0026301 | 0.0674181 |
| TAG52:5(FA16:0) | −0.3024300 | 0.0028230 | 0.0692749 |
| TAG54:6(FA16:0) | −0.2767250 | 0.0029219 | 0.0692749 |
| CE(FA18:1) | 0.0616905 | 0.0029728 | 0.0692749 |
| TAG52:6(FA16:1) | −0.3444020 | 0.0033464 | 0.0721775 |
| TAG52:5(FA18:3) | −0.2470372 | 0.0033575 | 0.0721775 |
| TAG52:5(FA18:2) | −0.3449757 | 0.0033789 | 0.0721775 |
| TAG54:7(FA18:2) | −0.5761714 | 0.0035175 | 0.0731075 |
| TAG54:7(FA20:4) | −0.2252724 | 0.0036766 | 0.0734343 |
| DAG(FA18:2/FA22:6) | −3.7042677 | 0.0038030 | 0.0734343 |
| TAG52:6(FA18:2) | −0.4073001 | 0.0038197 | 0.0734343 |
| TAG50:5(FA16:0) | −0.7027341 | 0.0041405 | 0.0766631 |
| TAG54:6(FA18:2) | −0.4742435 | 0.0041871 | 0.0766631 |
| TAG52:6(FA16:0) | −0.5787183 | 0.0044123 | 0.0788637 |
| TAG56:7(FA18:2) | −0.2425078 | 0.0045124 | 0.0788637 |
| TAG56:8(FA16:0) | −0.4646922 | 0.0046963 | 0.0802540 |
| TAG56:8(FA22:6) | −0.5023336 | 0.0049195 | 0.0821218 |
| TAG55:1(FA16:0) | −0.4700962 | 0.0050191 | 0.0821218 |
| TAG50:4(FA14:0) | −0.3123558 | 0.0060180 | 0.0959950 |
| TAG52:3(FA16:0) | −0.0962283 | 0.0061255 | 0.0959950 |
| TAG56:7(FA22:5) | −0.2748293 | 0.0065134 | 0.0959950 |
| TAG54:5(FA18:0) | −0.2489313 | 0.0065471 | 0.0959950 |
| TAG56:3(FA20:1) | 0.2700999 | 0.0066015 | 0.0959950 |
| TAG56:3(FA18:1) | 0.2131561 | 0.0066160 | 0.0959950 |
| TAG54:6(FA20:4) | −0.1866872 | 0.0068664 | 0.0977823 |
Data correspond to paired t test analyses of those data sets with R2/Q2 > 0.7 in the models predicted by OPLS‐DA and with p‐value adjusted by FDR < 0.1 in the multivariate analysis. Data is ordered according to the p‐value adjusted by FDR. CE, cholesteryl esters; DAG, diacylglycerol; FA, fatty acid; FDR, false discovery rate; PC, phosphatidylcholine; TAG, triacylglycerol; SM, sphingomyelin.