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Irinotecan chemotherapy can eliminate the wild-type and mutant cancer cells if there are no pro-tumor polarized immune cells at the start of treatment, despite a weak CTL response. The cytokine plot shows that the concentration of pro-tumor cytokines IL-4, IL-10 and IFN-α released by M2 macrophages and Th2 helper cells decrease over time, leading to the success of Irinotecan chemotherapy.
