Table S3.
Monotherapy dose and frequency.
| Treatment | Agent Type | Dose and Frequency | Infusion Time | Infusion Rate |
|---|---|---|---|---|
| Chemotherapy | Irinotecan [32] | 125 mg/m2 given weekly. This cycle may be repeated. | 1.5 hr | vC1 = 57.947 mg/L · day |
| Chemotherapy | (Hypothetical) | 125 mg/m2 given weekly. This chemotherapy agent was assumed to have the same cytotoxic properties on the tumor and immune cells as Irinotecan. It was assumed that tumor cells never develop resistance to this drug. This cycle may be repeated. | 1.5 hr | vC2 = 57.947 mg/L · day |
| Monoclonal antibody | Cetuximab [32] | Loading dose (LD): 400 mg/m2 (a one-time injection before giving the maintenance doses) Maintenance dose (MD): 250 mg/m2 (given weekly – start one week after giving LD and rest 2 weeks every 4 weeks). This cycle may be repeated. | LD: 2 hr MD: 1 hr | LD: vA = 139.072mg/L · day MD: vA = 173.840 mg/L · day Note: the same infusion term vA is used for cetuximab and for panitumumab, but their vA values are different. |
| Monoclonal antibody | Panitumumab [32] | 6 mg/kg every two weeks. No loading dose is required. This cycle may be repeated. | 1 hr | vA = 168.816 mg/L · day |
| Monoclonal antibody | Fresolimumab (anti-TGF-β) [43] | 3 mg/kg every two weeks. This cycle may be repeated. | 1.5 hr | vF = 56.272 mg/L · day |
| Monoclonal antibody | Anti-IL-10 Est. from [44] | 3 mg/kg every two weeks. This cycle may be repeated. | 1.5 hr | vAI10 = 21.0 mg L · day |
| RTK inhibitor | Sunitinib (anti-Treg) [45] | A Sunitinib capsule is given daily for 28 straight days followed by two weeks of rest. In total, 23.447 mg of sunitinib are administered per each 6-week cycle. This cycle may be repeated. | None | vs = 0.8374 mg/L · day |
| Adoptive cell transfer | NK cells [46] | An intravenous injection of 2 × 107 NK cells per kg is given weekly. This cycle may be repeated. | 1 hr | vNK = 5.627 × 108 cells/L · day |
| Adoptive cell transfer | CTL [47] | Five intravenous injections of 1 × 1010 CTL per m2 are given every 5 days and they are followed by 45 days of rest. This 65-day cycle may be repeated. | 1 hr | vCTL = 6.9536 × 109 cells/L · day |
| Cytokine Treatment | IL-2 [48] | 180,000 IU/kg injected over 15 minutes every 8 hours. | 0.25 hr | vIL2 = 2.0258 × 107 IU/L · day |
| Adoptive cell transfer | M1 macrophages | An intravenous injection of 2 × 107 M1 macrophages per kg is given weekly. This cycle may be repeated. | 1 hr | vM1 = 5.627 × 108 cells/L · day |
| Adoptive cell transfer | Th1 helper cells | An intravenous injection of 2 × 107 Th1 cells per kg is given weekly. This cycle may be repeated. | 1 hr | vT1 = 5.627 × 108 cells/L · day |