FIGURE 5.

Proximal versus distal supervised learning analysis. Whole exome and whole transcriptome sequencing data from the EPS sample cohort were integrated in a supervised learning framework to identify molecular features differentiating proximal versus distal EPS subtypes with cohesive biological relevance. (A) Heatmap of mutation, copy number variation and gene expression features differentially occurring in proximal vs distal EPS samples. (B) Interaction and connection network of genes identified in differential EPS subtype analysis. (C) Gene ontology analysis of genes identified during differential analysis. The top 20 ontology classes are reported here. The full list is provided in Table S3. Note: CXCR4, the receptor for CXCL12, is the mechanistic target of plerixafor and BL‐8040