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. 2022 Mar 7;66(7):2101004. doi: 10.1002/mnfr.202101004

Figure 4.

Figure 4

PTSO‐PTS modulates transcriptional pathways in cultured intestinal epithelial cells during Trichuris muris antigen stimulation . A) Gene ontology (GO) analysis of top upregulated pathways by PTSO‐PTS in CMT93 cells, compared to untreated cells. B) KEGG pathways upregulated following exposure of CMT93 cells to PTSO‐PTS, compared to untreated cells (p adj < 0.05). C) Heat map of top 10 up‐ and down‐regulated genes in CMT93 cells treated PTSO‐PTS, compared to untreated cells, D) GO analysis of top upregulated pathways following exposure of cells to T. muris E/S antigens, compared to untreated cells. E) KEGG pathways significantly upregulated by T. muris antigens in CMT93 cells, compared to untreated cells (p adj < 0.05). F) Heat map of top up‐ and down‐regulated genes by T. muris antigens, compared to untreated cells G) KEGG pathways upregulated in T. muris antigen‐treated cells exposed to by PTSO‐PTS, relative to only T. muris antigen treated cells (p adj < 0.05). H) Heat map of top up‐ and down‐regulated genes in T. muris antigen‐treated cells exposed to by PTSO‐PTS, relative to only T. muris antigen treated cells n = 3 per treatment group.