Figure 6.

PTSO‐PTS modulates the pro‐inflammatory transcriptional response in the mouse cecum. A) Top 10 most up‐ and down‐regulated genes in cecal tissue of Trichuris muris‐infected mice, relative to control, uninfected mice. B) Principal component analysis showing clustering of cecal tissue in uninfected mice, and mice infected with T. muris for 35 days and given control drinking water, or water supplemented with either 0.1 mg kg⁻¹ or 1 mg kg⁻¹ PTSO‐PTS. KEGG biological pathways significantly down‐regulated in cecal tissue of T. muris‐infected mice given either 0.1 C) mg kg⁻¹ or 1 mg kg⁻¹ D) PTSO‐PTS, relative to T. muris‐infected mice given control drinking water. E) qPCR validation of the expression of Tnf, Nos2, Saa2, and Mcpt1 in cecal tissue following 35 days of T. muris infection in mice given control drinking water, or water supplemented with either 0.1 mg kg⁻¹ or 1 mg kg⁻¹ PTSO‐PTS. Shown also are uninfected control mice given normal drinking water. * p < 0.05, ** p < 0.01, by ANOVA analysis. n = 4–5 per treatment group.