FIGURE 1.

Bias and variance of residuals. Mean residuals on the test set of a single replicate of the standard DCM (circles), DCM with initialization (diamonds), and corresponding SD (shaded areas) are shown for the extensive (a), routine (b), limited (c), and extremely limited (d) sampling strategies. Points were added for the purpose of comparison. Dotted line indicates zero residual error. Images on the left were trained on 120 patients, and images on the right on 20. Positive residuals indicate underestimation of FVIII levels while negative residuals indicate overestimation. DCM, deep compartment model; FVIII, factor VIII