FIGURE 4.

Examples of a priori perioperative predicted FVIII levels. DCM predictions represent the predicted FVIII levels by a single replicate of the DCM + VWF:Ag model. Stars represent observed FVIII levels. Both the prediction by the DCM (solid line) and the typical prediction from the NLME model (dotted line) are shown. For some patients, pre‐surgery prophylactic doses are also shown. DCM, deep compartment model; FVIII, factor VIII; NLME, nonlinear mixed‐effect modeling; VWF:Ag, von Willebrand factor antigen