TABLE 2.

Accuracy of a priori predicted FVIII levels for the independent OPTI‐CLOT data set

Model	Accuracy
NLME	21.9%
DCM	22.0 ± 0.417%
DCM + VWF:Ag	23.1 ± 1.12%

Note: Here we show the accuracy of the models as the percentage of predictions within 0.05 IU ml⁻¹ of observed FVIII levels ≥0.15. For observations <0.15 this threshold was set at 0.02 IU ml⁻¹. DCM accuracy is shown as the mean accuracy of five independent runs ± SD. The DCM + VWF:Ag model included VWF:Ag as an additional covariate. Bold text indicates the most accurate model.

Abbreviations: DCM, deep compartment model; FVIII, factor VIII; NLME, nonlinear mixed effect; VWF:Ag, von Willebrand factor antigen.