FIGURE 5.

Effect of Yoda1 on adult skeletal muscles. A, Representative recording traces of multi quantal endplate currents (EPCs) in the absence (Control) and presence of Yoda1 (5 μM). B, The real dynamics of multi quantal EPC amplitude changes during recording in a separate neuromuscular junction. C, Representative recording traces of miniature endplate currents (MEPCs) in the absence (Control) and presence of Yoda1 (5 μM). D, Averages of the EPC and MEPC amplitudes and MEPC frequencies in absence and in presence of Yoda1 (5 and 10 μM) expressed as percentage respect to controls (Ctrl); n = 6 animals, paired t test. E, Example of tetanic contraction before and after Yoda1 application (5 μM). F, Averages of tetanus force recorded before and after Yoda1 (5 and 10 μM) expressed as percentage respect to controls (Ctrl); n = 6 animals, paired t test