Table 3.
Identified SIRT6 activators.
| Compound | EC50 (μM) | Max Activation | Substrate | Ref. |
|---|---|---|---|---|
| MDL-800 | 10 | 22-fold | H3K9ac | [100,104] |
| MDL-801 | 4.1 | 25.1-fold | H3K9myr | [129] |
| MDL-811 | 7.1 | >15-fold | H3K9ac, H3K56ac | [97] |
| Cyanidin | 460 | 55-fold | H3K9ac | [130] |
| 4H-chromen | N/A | 40-fold | H3K9ac | [131] |
| Quercetin | 1200 | 2-fold | H3K9ac | [132] |
| UBCS039 | 38 | 3.5-fold | H3K9ac | [133] |
| CL5D | 15 | 50-fold | H3K9ac | [134] |
| Fucoidan | N/A | 335-fold | H3K9ac | [135] |
| Oleoylethanolamide | 3.1 | 2-fold | H3K9ac | [136] |
| Myristic acid | 246 | 35-fold | H3K9ac | [134] |
| Nitro-fatty acid | N/A | 40-fold | H3K9myr | [137] |
| 12q | 0.58 | >38-fold | Ac-RYQK(Ac)-AMC | [138] |
N/A, not available.