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. 2022 Jul 14;29(7):628–638. doi: 10.1038/s41594-022-00799-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, Fitting of the N- and C- termini model into the C1 and D2 symmetry LAFTER denoised maps. b, Fitting of the phosphorylated C- termini model into the sharpened C1 symmetry map. c, Views of the regulatory dimeric interface of the C1 and D2 symmetry LAFTER maps. The phosphorylated C-termini region density is symmetric in both maps. d, Predicted directions of the phosphorylated C-termini in C1 and D2 symmetry LAFTER denoised maps. The C-termini are predicted to continue away from the dimeric regulatory interface from two adjacent but different locations.