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. 2022 Jul 14;29(7):628–638. doi: 10.1038/s41594-022-00799-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a, 3D variability analysis components of all four states of GYS1 reported in this study. Initial and final frames are shown. The unique component of the inhibited like-state is highlighted by a red asterisk. Most movements are either slight flexing at the tetrameric interface or flexing of the N-terminal Rossman domains. b, Alignment of initial and final frames showing a global expansion from the central helical tetrameric interface. c, Close-up of the frames around the allosteric/G6P binding density. d, Namdinator fitted models into the initial and final frames showing a clear movement of the alpha-helices 13 from both subunits towards the regulatory helices.