Table 1.
Sociodemographic and cancer characteristics of women 40 and above in the USA by Race/Ethnicity (2010–2017)
| Variable | Number of patients (n = 277,127) |
Non-Hispanic White (n = 191,777) |
Non-Hispanic Black (n = 28,250) |
Hispanic (All races) (n = 30,813) |
Other (n = 26,287) |
Pearson Chi-square |
|---|---|---|---|---|---|---|
| Surgery | 86.4692*** | |||||
| Patients with surgery recommended but not performed, patients refused | 1,486 | 938 (0.49) | 257 (0.91) | 140 (0.45) | 151 (0.57) | |
| Patients who received surgery | 275,641 | 190,839 (99.51) | 27,993 (99.09) | 30,673 (99.55) | 26,136 (99.43) | |
| Subtypes | 4.6exp(3)*** | |||||
| Luminal A | 209,996 | 149,932 (78.18) | 17,973 (63.62) | 22,437 (72.82) | 19,654 (74.77) | |
| Luminal B | 27,478 | 17,776 (9.27) | 3,064 (10.85) | 3,585 (11.63) | 3,053 (11.61) | |
| HER2 enriched | 10,838 | 6,530 (3.40) | 1,456 (5.15) | 1,438 (4.67) | 1,414 (5.38) | |
| Triple negative | 28,815 | 17,539 (9.15) | 5,757 (20.38) | 3,353 (10.88) | 2,166 (8.24) | |
| Age at diagnosis | 5.7exp(3)*** | |||||
| 40–49 | 48,079 | 28,312 (14.76) | 5,566 (19.70) | 7,963 (25.84) | 6,238 (23.73) | |
| 50–59 | 72,810 | 47,643 (24.84) | 8,443 (29.89) | 9,225 (29.94) | 7,499 (28.53) | |
| 60–69 | 81,609 | 58,454 (30.48) | 8,031 (28.43) | 7,819 (25.38) | 7,305 (27.79) | |
| 70–79 | 51,583 | 39,045 (20.36) | 4,509 (15.96) | 4,225 (13.71) | 3,804 (14.47) | |
| 80+ | 23,046 | 18,323 (9.55) | 1,701 (6.02) | 1,581 (5.13) | 1,441 (5.48) | |
| Tumor grade | 4.2exp(3)*** | |||||
| Grade I; well differentiated | 69,674 | 52,293 (27.27) | 4,722 (16.72) | 6,675 (21.66) | 5,984 (22.76) | |
| Grade II; moderately differentiated | 125,240 | 88,117 (45.95) | 11,160 (39.50) | 13,796 (44.77) | 12,167 (46.29) | |
| Grade III; poorly differentiated | 82,213 | 51,367 (26.78) | 12,368 (43.78) | 10,342 (33.56) | 8,136 (30.95) | |
| Tumor site | 367.0890*** | |||||
| Nipple | 1,008 | 647 (0.34) | 101 (0.36) | 142 (0.46) | 118 (0.45) | |
| Central portion of the breast | 14,156 | 9,912 (5.17) | 1,234 (4.37) | 1,516 (4.92) | 1,494 (5.68) | |
| Upper-inner quadrant of the breast | 40,050 | 27,181 (14.17) | 4,102 (14.52) | 4,486 (14.56) | 4,281 (16.29) | |
| Lower-inner quadrant of the breast | 17,578 | 12,006 (6.26) | 2,098 (7.43) | 1,875 (6.09) | 1,599 (6.08) | |
| Upper-outer quadrant of the breast | 108,230 | 75,762 (39.51) | 11,157 (39.49) | 11,808 (38.32) | 9,503 (36.15) | |
| Lower-outer quadrant of the breast | 23,767 | 16,572 (8.64) | 2,442 (8.64) | 2,580 (8.37) | 2,173 (8.27) | |
| Axillary tail of the breast | 1,305 | 885 (0.46) | 197 (0.70) | 135 (0.44) | 88 (0.33) | |
| Overlapping lesion of the breast | 71,033 | 48,812 (25.45) | 6,919 (24.49) | 8,271 (26.84) | 7,031 (26.75) | |
| Tumor stage | 1.3exp(3)*** | |||||
| Localized only | 197,500 | 139,928 (72.96) | 18,501 (65.49) | 20,277 (65.81) | 18,794 (71.50) | |
| Regional, direct extension only | 3,423 | 2,437 (1.27) | 368 (1.30) | 332 (1.08) | 286 (1.09) | |
| Regional, lymph nodes only | 68,290 | 44,318 (23.11) | 8,323 (29.46) | 9,169 (29.76) | 6,480 (24.65) | |
| Regional, both direct extension and lymph nodes | 7,914 | 5,094 (2.66) | 1,058 (3.75) | 1,035 (3.36) | 727 (2.77) | |
| Marital status | 1.1exp(4)*** | |||||
| Married/Domestic Partner | 165,394 | 118,800 (61.99) | 10,678 (37.80) | 17,991 (58.39) | 17,845 (67.89) | |
| Divorced | 32,038 | 22,181 (11.57) | 4,457 (15.78) | 3,456 (11.22) | 1,944 (7.40) | |
| Widowed | 37,364 | 27,269 (14.22) | 4,096 (14.50) | 3,142 (10.20) | 2,857 (10.87) | |
| Separated | 3,073 | 1,407 (0.73) | 681 (2.41) | 724 (2.35) | 261 (0.99) | |
| Never married | 39,258 | 22,040 (11.49) | 8,338 (29.52) | 5,500 (17.85) | 3,380 (12.86) | |
| Year of diagnosis | 348.4360*** | |||||
| 2010 | 30,717 | 22,092 (11.52) | 2,999 (10.62) | 2,953 (9.58) | 2,673 (10.17) | |
| 2011 | 31,810 | 22,487 (11.73) | 3,110 (11.01) | 3,375 (10.95) | 2,838 (10.80) | |
| 2012 | 33,035 | 23,131 (12.06) | 3,415 (12.09) | 3,521 (11.43) | 2,968 (11.29) | |
| 2013 | 34,302 | 23,840 (12.43) | 3,480 (12.32) | 3,753 (12.18) | 3,229 (12.28) | |
| 2014 | 34,957 | 24,208 (12.62) | 3,629 (12.85) | 3,838 (12.46) | 3,282 (12.49) | |
| 2015 | 36,769 | 25,244 (13.16) | 3,716 (13.15) | 4,210 (13.66) | 3,599 (13.69) | |
| 2016 | 37,470 | 25,276 (13.18) | 3,899 (13.80) | 4,559 (14.80) | 3,736 (14.21) | |
| 2017 | 38,067 | 25,499 (13.30) | 4,002 (14.17) | 4,604 (14.94) | 3,962 (15.07) | |
| Median income | 1.8exp(4)*** | |||||
| < $35,000 | 3,797 | 2,946 (1.54) | 645 (2.28) | 135 (0.44) | 71 (0.27) | |
| $35,000–$44,999 | 19,617 | 13,749 (7.17) | 4,795 (16.97) | 840 (2.73) | 233 (0.89) | |
| $45,000–$54,999 | 40,359 | 29,846 (15.56) | 5,508 (19.50) | 3,940 (12.79) | 1,065 (4.05) | |
| $55,000–$64,999 | 66,982 | 43,241 (22.55) | 7,620 (26.97) | 10,239 (33.23) | 5,882 (22.38) | |
| $65,000–$74,999 | 58,796 | 42,341 (22.08) | 4,776 (16.91) | 7,209 (23.40) | 4,470 (17.00) | |
| > $75,000 | 87,576 | 59,654 (31.11) | 4,906 (17.37) | 8,450 (27.42) | 14,566 (55.41) | |
| Urban–Rural | 6.7exp(3)*** | |||||
| Counties in metropolitan areas greater than 1 million | 172,590 | 112,780 (58.81) | 19,349 (68.49) | 21,765 (70.64) | 18,696 (71.12) | |
| Counties in metropolitan areas of 250 k to 1 million | 58,086 | 40,567 (21.15) | 4,942 (17.49) | 6,737 (21.86) | 5,840 (22.22) | |
| Counties in metropolitan areas less than 250 k | 19,049 | 14,817 (7.73) | 1,950 (6.90) | 1,440 (4.67) | 842 (3.20) | |
| Non-metropolitan counties adjacent to a metropolitan area | 15,984 | 13,759 (7.17) | 1,505 (5.33) | 499 (1.62) | 221 (0.84) | |
| Non-metropolitan counties non-adjacent to a metropolitan area | 11,418 | 9,854 (5.14) | 504 (1.78) | 372 (1.21) | 688 (2.62) | |
| Radiation therapy | 983.2506*** | |||||
| No | 106,188 | 71,589 (37.33) | 10,494 (37.15) | 12,957 (42.05) | 11,148 (42.41) | |
| Yes | 161,811 | 114,632 (59.77) | 16,559 (58.62) | 16,347 (53.05) | 14,273 (54.30) | |
| Missing | 9,128 | 5,556 (2.90) | 1,197 (4.24) | 1,509 (4.90) | 866 (3.29) | |
| Chemotherapy | 3.0exp(3)*** | |||||
| No | 171,081 | 124,213 (64.77) | 14,039 (49.70) | 17,061 (55.37) | 15,768 (59.98) | |
| Yes | 106,046 | 67,564 (35.23) | 14,211 (50.30) | 13,752 (44.63) | 10,519 (40.02) | |
| Pathological inflammatory breast cancer | 0.074 | |||||
| No | 276,913 | 191,635 (99.93) | 28,223 (99.90) | 30,781 (99.90) | 26,274 (99.95) | |
| Yes | 214 | 142 (0.07) | 27 (0.10) | 32 (0.10) | 13 (0.05) | |
Values are n (% of column total). For the p-value, ns indicates not significant, *p < 0.05, **p < 0.01, ***p < 0.001
HER2 Human epidermal growth factor receptor 2