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. 2022 Jul 15;13(7):613. doi: 10.1038/s41419-022-05074-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Scotopic a-wave (A, C, E), scotopic b-wave (A, C, E), and photopic b-wave (B, D, F) analyses were performed on 1-month-old (A, B), 4-month-old (C, D), and 6-month-old (E, F) IGF-1R-WT and ^rodIgf-1r^−/− mice. Six-week-old IGF-1R-WT and ^retIgf-1r^−/− mice were subjected to ERG and we measured scotopic a-wave, scotopic b-wave (G), and photopic b-wave (H) amplitudes. Scotopic a-wave and scotopic b-wave amplitudes were carried out at different flash intensities (−3.4, −2.4, −1.4, −0.4, 0.6, 1.6, and 2.6 log cd s/m²), whereas photopic b-wave amplitudes were performed at a flash intensity of 3.3 log cd s/m². Data are mean ± SEM (n = 8). Two-way ANOVA was used to determine the statistical significance. The data were corrected for multiple comparisons by controlling the False Discovery Rate using a two-stage linear step-up procedure of the Benjamini, Krieger, and Yekutieli test. *p < 0.05; **p < 0.001.