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. 2022 Jul 15;13(7):613. doi: 10.1038/s41419-022-05074-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Prefer-fixed sections of 2-month-old (A, B) and 4-month-old (D, E) IGF-1R-WT and ^rodIgf-1r^−/− mouse retinas were stained with hematoxylin and eosin and examined for morphology. Plots of total retinal thickness of 2-month-old (C) and 4-month-old (F) IGF-1R-WT and ^rodIgf-1r^−/− mouse retinas were measured from the optic nerve head (ONH) in the inferior and superior regions of the retinas of IGF-1R-WT and ^rodIgf-1r^−/− mice. Data are mean ± SEM (n = 6). Two-way ANOVA with the Bonferroni test was used to determine the statistical significance. There was a significantly greater loss of rod nuclei in both hemispheres of the ^rodIgf-1r^−/− mouse retinas than in the IGF-1R-WT retinas (p < 0.001). OCT showed decreased OPL-ONL and IS-EPTRS in ^rodIgf-1r^−/− mice (G, H). Data are mean ± SEM (n = 8). An unpaired t test with Welch’s correction was used to determine the significance. *p < 0.001. In situ localization of apoptosis using TUNEL staining (I). Data are mean ± SEM (n = 8). An unpaired nonparametric Mann-Whitney test was used to determine the significance. *p < 0.001.