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. 2022 Jul 15;5:707. doi: 10.1038/s42003-022-03668-3

Fig. 3. Active conformation of the MrgD receptor.

Fig. 3

a Superposition of the β-alanine-bound active MrgD receptor (cyan), active Angiotensin II type1 (AT1) receptor (salmon, PDB code: 6OS0), and antagonist-bound AT1 receptor (gray, PDB code: 4YAY) models at two different angles. The movement of TM6 and TM7 in the MrgD receptor relative to inactive AT1R is indicated by black arrows. b–d Detailed views of the three motifs: PIF motif (b), DRY motif (c), and NPxxY motif (d). Each residue in the motifs is shown as a stick model. The difference in the orientation of the side chains from the inactive AT1R is shown in black arrows. The alignment is based on only the receptor portion.