Fig. 9. Lipid binding site near the turret domain of Kv3.1a resembles known drug binding sites in other channels.

a Kv3.1a residues in the pore domain (S6 in yellow, PH in green) involved in hydrophobic interactions with the fatty acid tails (black) of the lipid bound to the groove at the PD/VSD interface. Residues from the nearby S1/S2 linker are coloured in pink. K⁺ ions are represented as purple spheres. b Binding site for agonist AM-0883 (white) between S6 (yellow) and PH (green) of TRPC6 (pdb: 6UZ8).