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. 2022 Jan 20;29(7):1379–1394. doi: 10.1038/s41418-021-00926-5

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© The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Cell viability assay of GSCs with H2AZ2 KD or 3 days of E2Fi treatment (n = 6) (mean ± SD). ***p < 0.001. Gene set enrichment map of pathways containing genes downregulated or upregulated upon 15 μM E2Fi (3 days) treatment (B) or H2AZ2 depletion (C) of GSC. Nodes represent gene sets (pathways) that were significantly enriched in the comparison treated vs. control samples (FDR < 0.05). D Venn diagram showing the number of overlapped genes among the downregulated genes upon 15 μM E2Fi treatment (3 days) or H2AZ2 depletion. E Western blot analysis of p-STAT3 and STAT3 protein levels in H2AZ2 KD or 15 μM E2Fi-treated GSC. F Quantification of p-STAT3 band intensities in (E) when normalized to the STAT3 control (n = 3) (mean ± SD). *p < 0.05; **p < 0.01. A, F Two-tailed unpaired Student’s t test.