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. 2022 Jul 15;12:12078. doi: 10.1038/s41598-022-15244-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Design and Structural Characterization of the HA-CPNs. (A) Schematic structure of HA-CPNs; (B) SANS form factor for a dilute dispersion of HA-CNPs in D₂O fit with a solid line using an empirical Guinier-Porod model. The slope in the Porod region of the plot shows a q-dependency of q^−4.2, suggesting a spherical particle shape; (C) Real-space distance distribution function from an inversion approach demonstrating uniformity consistent with spherical particles of maximum dimension D_max; (D) Kratky plot demonstrates a peak and plateau characteristic of compact globular structures. (E) Dynamic light scattering of HA-CPNs. Average diameter of 109 nm; (F) Transmission electron microscopy image of HA-CPNs. Scale bar of 50 nm.