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Comparison of the new HA-CPNs with selected previously reported nanomaterials against GBM.
| Materials | External stimuli | Selectivity | Evidence of transport across BBB | Demonstrated intrinsic toxicity to GBM in vivo | Evaluated in primary patient cultures | Refs |
|---|---|---|---|---|---|---|
| HA-MnO2 nanoparticles | Magnetic field | Yes | No | No | No | 32 |
| HA liposomes | None | Yes | Yes | Yes | No | 31 |
| HA lipid nanoparticles | None | Yes | Yes | No | No | 8 |
| DPP-based CPNs | Laser irradiation | No | No | No | No | 49 |
| HA-CPNs (this work) | None | Yes | Yes | Yes | Yes | – |
