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. 2022 Jul 16;41(10):1429–1439. doi: 10.1016/j.healun.2022.07.008

Figure 2.

Figure 2

Antibody response after three vaccine doses in lung transplant recipients with history of COVID-19 (n = 10). (A) Anti-RBD IgG titers expressed in BAU/mL before vaccination and from two weeks to two months after the third dose. (B) Neutralizing antibody titers assessed by pseudovirus-based assay against D614G, delta and omicron variants. The dotted horizontal black line indicates the cutoff for positivity (1:40 dilution). (C) Dynamics of anti-RBD IgG titers expressed in BAU/mL over time after the third vaccine dose (n = 11 additional samples collected from 9 patients during follow-up). (A and C) The dotted lines indicate the positivity threshold (7.1 BAU/mL) and the threshold of 264 BAU/mL used in French recommendations to guide prophylactic strategy in immunosuppressed patients. BAU, Binding Antibody Units; ED50, half-maximal effective dilution; RBD, receptor-binding domain.