Table 2.
Multivariable Analysis on Antibody Response in LTR to a Three-Dose Regimen of COVID-19 mRNA Vaccine
| Variable | B | SEB | eB (adjusted odds ratio) | 95% CI | p-value |
|---|---|---|---|---|---|
| Intercept | −8.758 | 2.599 | - | - | - |
| History of treated allograft acute rejection | 0.487 | 0.553 | 1.627 | 0.550-4.808 | 0.379 |
| Time between lung transplantation and vaccination (per 1 year increment) | 0.038 | 0.052 | 1.039 | 0.939-1.150 | 0.463 |
| BNT162b2 vaccine (vs mRNA-1273) | 1.906 | 0.688 | 6.724 | 1.745-25.916 | 0.006 |
| Time between first and second doses (per 1 day increment) | 0.123 | 0.064 | 1.131 | 0.998-1.283 | 0.055 |
| Time between third dose and antibody testing | |||||
| (per 1 day increment) | −0.011 | 0.017 | 0.989 | 0.957-1.022 | 0.516 |
| Prevaccine TTV viral load ≥6.2 log10 cp/mL | 2.883 | 0.907 | 17.866 | 3.019-105.716 | 0.001 |
| MMF/MPA | 1.554 | 0.600 | 4.730 | 1.458-15.343 | 0.010 |
| Tacrolimus | 0.303 | 0.633 | 1.354 | 0.391-4.684 | 0.632 |
| Steroids | 0.769 | 1.001 | 2.157 | 0.303-15.335 | 0.442 |
B, regression coefficient; CI, confidence interval; MMF/MPA, mycophenolate mofetil/mycophenolic acid; SE, standard error; TTV, Torque teno virus.
Multivariable logistic regression analysis of the risk to be a non-responder was performed using SPSS 28.0 (IBM Statistics). Factors independently associated with poor vaccine response (p < 0.05) are in bold. Overall model statistics: χ2 = 42.407, p-value <0.001.