Figure 3.
Estimated range in frequency and absolute number of various disease classes
Left, Distinct diseases, including the concurrent coincidence of three primary immunodeficiencies, where the prevalence for chronic granulomatous disease corresponds to mutations in the autosomal NCF1 gene, encoding a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. Right, the oval-shaped areas correspond to various disease classes. To compensate for that phenotype conversion only appears in certain disease combinations a correction coefficient was introduced, which for three concurrent diseases amounts to [⅓]3 = ½7.