Fig. 6.

IκB signalling in human skeletal muscle in response to incremental exercise to exhaustion in normoxia and severe hypoxia, and post-exercise ischaemia. Levels of protein expression of (A) Total IκBα, (B) pThr¹⁹/Ser²³ IκBß, and (C) Total IκBß. Nx: normoxia session (F_IO₂ = 0.21, P_IO₂ = 143 mmHg); Hyp: severe normobaric hypoxia session (F_IO₂ = 0.104, P_IO₂ = 73 mmHg); Pre: before exercise; Post: 10 s after exercise cessation during ischaemic recovery; Oc1m: 60 s after exercise cessation during ischaemic recovery; FC1m: 60 s after exercise cessation during recovery with free circulation. For panels (A) and (C), n = 11 for all conditions except for Oc1m Nx (n = 9) and for panel (B), n = 11 for all conditions except for Oc1m Nx (n = 9), Post Hyp (n = 10) and FC1m (n = 10). See Fig. 1 for a detailed description of the experimental phases. The statistical analysis was performed with logarithmically transformed data for Total IκBß. Values presented are means ± standard errors and expressed in arbitrary units (a.u.). & mean of the pre-exercise conditions in normoxia and hypoxia compared with the mean of the four post-exercise conditions (p = 0.008); †p < 0.05 vs. Pre Nx; *p < 0.05 vs. Pre Hyp; #p < 0.05 vs. Post Hyp; §p < 0.05 vs. Oc1m Hyp.