Figure 1.

QSP model diagram

The model is comprised of four compartments: central, peripheral, tumor, and tumor-draining lymph node, which together describe cycles of immune activation in lymph nodes, T cell trafficking to the tumor, killing of cancer cells, immune evasion, and antigen release and lymphatic transport (Wang et al., 2021). nT, naive T cell; aT, activated T cell; NO, nitric oxide; Arg-I, arginase I; Treg, regulatory T cell; Teff, effector T cell; Th, helper T cell; Mac, macrophage; mAPC, mature antigen-presenting cell. Cytokine degradation and cellular clearance are omitted in the figure.