Figure 2.

Integration of the macrophage module into the QSP model

(A) Macrophage module diagram. Created with BioRender.com.

(B) Model-predicted overall inhibitory effect on phagocytosis by immune checkpoint molecules $\left(H_{Mac,C}\right)$. Experimentally measured increases of phagocytosis activity are compared with the decrease of phagocytosis rate because of checkpoint interactions in the model $\left(1-H_{Mac,C}\right)$. Statistical significance was calculated by Wilcoxon test.

(C) Time-dependent profile of T cell subsets, macrophages, and myeloid-derived suppressor cells (MDSC) from baseline simulation.

(D) Global sensitivity analysis on phagocytosis submodule. Partial-rank correlation coefficients (PRCC) are reported to test associations between the overall inhibitory effect of checkpoint molecules on phagocytosis and parameters of interest.

(E) Global sensitivity analysis on macrophage module. PRCC values are reported to test associations between the tumor volume and parameters of interest.